A cura di Alessandra Russo. Specialista in Tossicologia Medica. Messina
|
Principio attivo |
Effetto |
|
Aripiprazolo (1,2) |
Possibile aumento dell’esposizione ad aripiprazolo |
|
Ciclosporina (3) |
Possibile riduzione della risposta terapeutica alla ciclosporina |
|
Lofexidina (4) |
Possibile aumento dei livelli plasmatici della lofexidina |
|
Metoprololo (5) |
Possibile aumento dei livelli di metoprololo; possibile aumento del rischio di bradicardia |
|
Nortriptilina (6) |
Possibile aumento del rischio di tossicità da nortriptilina (affaticamento, vertigini, perdita dell’appetito) |
|
Warfarin (7,8) |
Possibile alterazione dell’efficacia del warfarin |
Bibliografia
- Product Information. ABILIFY(R) oral tablets, oral solution, intramuscular injection, aripiprazole oral tablets, oral solution, intramuscular injection. Otsuka America Pharmaceutical, Inc. (per FDA), Rockville, MD, Jun 2014.
- Product Information. ARISTADA INITIO (TM) intramuscular extended-release injection, aripiprazole lauroxil intramuscular extended-release injection. Alkermes, Inc (per manufacturer), Waltham, MA, Jun 2018.
- Lo ACY, et al. The interaction of terbinafine and cyclosporine A in renal transplant patients. Br J Clin Pharmacol 1997; 43: 340-341.
- Product Information. LUCEMYRA(TM) oral tablets, lofexidine oral tablets. US WorldMeds LLC (per FDA), Louisville, KY, May 2018.
- Bebawi E, et al. A metoprolol-terbinafine combination induced bradycardia. Eur J Drug Metab Pharmacokinet 2015; 40: 295-299.
- van der Kuy PHM, et al. Nortriptyline intoxication induced by terbinafine (letter). BMJ 1998; 316: 441.
- Gupta AK, Ross GS. Interaction between terbinafine and warfarin. Dermatology 1998; 196: 266-267.
- Warwick JA, Corrall RJ. Serious interaction between warfarin and oral terbinafine. BMJ 1998; 316: 440.
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